Publications
The anti cancer effects of jasmonates and their unique mode of action have been published by the collaborators of Sepal Pharma in multiple renowned reviews.Kniazhanski T, Jackman A, Heyfets A, Gonen P, Flescher E, Sherman L
Methyl jasmonate induces cell death with mixed characteristics of apoptosis and necrosis in cervical cancer cells.
Cancer Let. (In press)
Goldin N, Arzoine L, Israelson A, Zaslavsky Z, Bravman T, Bronner V, Notcovich N, Shoshan-Barmatz V and Flescher E
Methyl jasmonate binds to and detaches mitochondria-bound hexokinase
Oncogene 27, 4636-4643, 2008
Galluzzi L, Kepp O, Tajeddine N and Kroemer G
Disruption of the hexokinase-VDAC complex for tumor therapy (Commentary)
Oncogene 27, 4633-4635, 2008
Reischer D, Heyfets A, Shimony S, Nordenberg J, Kashman Y, Flescher E
Effects of natural and novel synthetic jasmonates in an experimental metastasis model.
Br. J. Pharmacol. 150:738-749, 2007
Heyfets A, Flescher E
Cooperative cytotoxicity of methyl jasmonate with anti-cancer drugs and 2-deoxy-D-glucose.
Cancer Let. 250:300-310, 2007
Flescher E
Jasmonates in cancer therapy.
Cancer Let. 245: 1-10, 2007
Goldin N, Heyfets A, Reischer D, Flescher E
Mitochondria-mediated ATP depletion by anti-cancer agents of the jasmonate family.
J. Bioenerg. Biomembr. 39: 51-57, 2007
Flescher E
Jasmonates - a new family of anti-cancer agents.
Anti-Cancer Drugs 16: 911-916, 2005
Fingrut O, Reischer D, Rotem R, Goldin N, Altboum I, Zan-Bar I, Flescher E
Jasmonates induce non-apoptotic death in high-resistance mutant p53-expressing Blymphoma cells
Br. J. Pharmacol. 146:800-808, 2005
Rotem R, Heyfets A, Fingrut O, Blickstein D, Shaklai M, Flescher E
Jasmonates: novel anticancer agents acting directly and selectively on human cancer cell mitochondria.
Cancer Res. 65:1984-1993, 2005
Rotem R, Fingrut O, Moskovitz J, Flescher E
The anticancer agent methyl jasmonate induces activation of stress-regulated c-Jun
N-terminal kinase and p38 protein kinase in human lymphoid cells.
Leukemia 17:2230-2234, 2003
Fingrut O, Flescher E
Plant stress hormones suppress the proliferation and induce apoptosis in human cancer cells.
Leukemia 16:608-616, 2002
